Virtual clinical trial populations in motor neuron disease

Prof. Ammar Al-Chalabi
PI Prof. Ammar Al-Chalabi
Co-investigators Dr Alfredo Iacoangeli
Prof. Ben Carter
PI organisation King’s College London
Funding awarded £642,768
Completion date 31st March 2026 (18 months)

This project aims to develop a set of digital twins of people with motor neuron disease. We will then carry out a clinical trial using computer simulations to replicate what would happen in real life. We can use that knowledge to improve the design of a real trial, making it shorter and more efficient. The digital twins will also mean that in the real trial, fewer people will need to take a blank version of the treatment (placebo) and more people will be able to take the real treatment, which is very important in a terminal condition like motor neuron disease.

Prof. Ammar Al-Chalabi